My game save was lost after saving during the room called the "Crew's Quarters" with partners being Alice and Phi. I saved to take a break because I was stuck on one of the puzzles, came back and was greeted with the black screen of nothing.
Reader Compc sends in this tale of woe...
The 3DS version of Zero Escape: Virtue's Last Reward has a game breaking bug that will corrupt your save file! If you save your game during the escape section in the PEC room, the game will crash after a little while and when you try to load your save, the game will tell you that the save data is corrupt and that it needs to be deleted.
Let's hope Aksys gets a fix out for this one soon. Losing a save file in this game would be oh-so painful!