Like you RMC, the biggest issue for me is the input lag. I noticed last night that when simply jumping up on platforms, I was trying to do it fast and timed the jumps as I saw on screen. Miriam simply walked off the edge when I got half way up, so I had to do it again.
A close second is inconsistent textures. Some areas look absolutely fine, while others looks like they are straight out of a high school 3D modelling class. I'd rather they all be the same. It's jarring to have some scenes looks quite nice, and others look like trash.
I'm going to wait until they patch things, which is a shame since I backed this all those years ago. But hey, I'll just pretend they delayed it