The latest bit of gameplay from Monster Hunter Rise: Sunbreak gives a look at how Follower Quests and NPCs work together.
In the clip above, you can see that NPCs have the ability to set traps and mount monsters to help you during a hunt. Furthermore, if the NPC you are escorting through a Follower Quest goes down, you won’t fail the quest overall. You can just walk over to the NPC and revive them when you have a moment.
Taking on Follower Quests will strengthen your relationship with the NPC, and there is a wide variety of NPCs for you to take on your hunts. Followers will even differ depending on your region!